%PDF-1.7
%
573 0 obj
<>
endobj
562 0 obj
<>
endobj
572 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2020-12-14T23:17:03-08:00
2020-09-22T13:48:56+08:00
2020-12-14T23:17:03-08:00
uuid:48e81084-29d0-438f-a63f-b14703b364ae
uuid:a1787e99-1dd1-11b2-0a00-9000588fc8ff
application/pdf
Science Journals — AAAS
endstream
endobj
574 0 obj
<>
endobj
558 0 obj
<>
endobj
560 0 obj
<>
endobj
5 0 obj
<>
endobj
145 0 obj
<>
endobj
251 0 obj
<>
endobj
247 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 248 0 R/Type/Page>>
endobj
365 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 366 0 R/Type/Page>>
endobj
682 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
690 0 obj
[695 0 R 696 0 R 697 0 R 698 0 R 699 0 R 700 0 R]
endobj
691 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 611.99997 Tm
(chemistry)Tj
0 1 TD
(Synthetic connectivity, emergence, and self-regeneration in the network \
of prebiotic)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 590.99997 Tm
(Miroslaw Dygas, Sara Szymkuc and Bartosz A. Grzybowski)Tj
T*
(Agnieszka Wolos, Rafal Roszak, Anna Zadlo-Dobrowolska, Wiktor Beker, Bar\
bara Mikulak-Klucznik, Grzegorz Sp\363lnik,)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 544.99997 Tm
(DOI: 10.1126/science.aaw1955)Tj
5.50301 1 Td
( \(6511\), eaaw1955.)Tj
/T1_0 1 Tf
-1.668 0 Td
(369)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 145.45605 456.99979 Tm
(, this issue p. eaaw1955)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-3.125 1 Td
(authors validated experimentally.)Tj
52.18792 1.00001 Td
(the)Tj
-52.18792 0 Td
(network predicted a variety of previously unappreciated routes to bioche\
mically relevant compounds, several of which )Tj
T*
(such as cyanide, water, and ammonia, and then iteratively to each succes\
sive generation of products. The resulting)Tj
0 1.00001 TD
(document each such reaction class and then wrote software that applied t\
he reactions first to the simplest compounds )Tj
40.73694 1 Td
( scoured the literature to)Tj
/T1_2 1 Tf
-2.168 0 Td
(et al.)Tj
/T1_1 1 Tf
-38.56894 0 Td
(the building blocks of proteins, nucleic acids, and lipids from simple p\
recursors. Wolos )Tj
3.125 1 Td
(Chemists seeking to understand the origins of life have published a wide\
range of reactions that may have yielded)Tj
/T1_0 1 Tf
-3.125 1.00001 Td
(Mapping primordial reaction networks)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 391 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 389 Tm
(http://science.sciencemag.org/content/369/6511/eaaw1955)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 348.99997 Tm
(MATERIALS)Tj
T*
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 353 Tm
(http://science.sciencemag.org/content/suppl/2020/09/23/369.6511.eaaw1955\
.DC1)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 313 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 302.99997 Tm
(http://science.sciencemag.org/content/369/6511/eaaw1955#BIBL)Tj
0 g
0 1 TD
(This article cites 153 articles, 13 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 277 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 275 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
521 114 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
8 0 0 8 357.45605 93.99997 Tm
( is a registered trademark of AAAS.)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-32.125 0 Td
(Science, 1200 New York Avenue NW, Washington, DC 20005. The title )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 71.99997 Tm
(Science. No claim to original U.S. Government Works)Tj
T*
(Copyright \251 2020 The Authors, some rights reserved; exclusive license\
e American Association for the Advancement of)Tj
ET
BT
/T1_1 1 Tf
0 -8 8 0 575 331.09607 Tm
(on December 14, 2020)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
694 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(