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Research Fellow

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Kandere-Grzybowska, Kristiana Telephone : 052-217-5516

  • Profile

    Kristiana Kandere-Grzybowska, Ph.D.
    Researcher, IBS
    Adjunct Professor, UNIST

    Biography 

    Kristiana Kandere-Grzybowska graduated summa cum laude in biology from the College of Saint Rose (Albany, NY, USA) in 1998. She obtained a doctoral degree in biochemistry from Tufts University School of Medicine (Boston, MA, USA) in September 2003 (with T.C. Theoharides). From 2003-2006 she was a Department of Defense (DOD) postdoctoral fellow (with G. G. Borisy) at Northwestern University (Chicago, Illinois, USA). From 2006-2014 she was Research Assistant Professor in the Department of Chemical and Biological Engineering at Northwestern University and worked with Prof. Bartosz A. Grzybowski. She joined IBS Center for Soft and Living Matter in 2015.


    Scientific Interests

    Dynamic live cell imaging; micro/nano-fabrication and intracellular/cytoskeleton dynamics and patterns of cancer cell motility; using nanomaterials to target cancer cells

    Highlights of Scientific Contributions 

    Kandere-Grzybowska pioneered the microetching method (also called Wet Stamping, or WETS) for cell micropatterning that is compatible with various high resolution live-cell imaging modalities, such as wide-field digital fluorescence, confocal and total internal reflection (TIRF) microscopies (Nature Methods, 2005). She and colleagues then used WETS to study intracellular cellmotility sub-processes, such as cell polarization (Soft Matter, 2010), microtubule guidance (J. Cell Sci., 2012) and cell micromechanics (Adv. Mater., 2012) in micropatterned cells with geometrically-defined shapes (also called Treadmills). WETS were also used to demonstrate that asymmetric continuous ratchet-shape patterns (Ratchets) direct cell motions. Specifically, motions of cancer cells were directed in the direction opposite to that by normal cells leading to partial sorting out of mixed cell populations. Finally, using continuous linear patterns (or Lines or 1D microtracks) generated by WETS revealed that metastatic cells, but not non-metastatic cells, use fundamentally distinct cell migration patterns than non-metastatic cells (Submitted, 2015).  Kandere-Grzybowska is an author of 29 publications which have been cited 1536 times (based on Google Scholar).